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The Role of Oxidative Stress in Alzheimer’s Disease

What is Alzheimer’s Disease?

Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by severe dementia. Like dementia, AD causes problems with memory loss, thinking and behavior which worsen over time until the patient is unable to respond to the environment. Unlike dementia, AD is not a normal part of aging and has been linked to many causes involving genetics, enzyme dysfunction, and neuronal cell death.

 

How does AD work?

In the brain, certain proteins called amyloid beta proteins are broken down by defective enzymes to form amyloid plaques. These plaques aggregate in between neurons which inhibit cell communication and eventually lead to cell death and therefore brain tissue degradation. There have been many different proposed pathways and precursors of the initiation of the breakdown of these proteins, though they all seem to work together to cause AD.

 

How does oxidative stress effect AD?

Oxidative stress is one of these pathways that has been correlated to the initiation and propagation. It has been shown through biochemical studies that oxidation modifies a specific enzyme involved in amyloid degradation that renders the enzyme defective. Whether or not oxidative stress is the sole or key cause of Alzheimer’s Disease, it is beneficial to make sure your body has the right balance of antioxidants in order to help prevent or treat symptoms of this neurodegenerative disease.  OPCs are powerful antioxidants which can help to balance oxidative stress.  To view our Super Isotonic OPC Formula click here.

 

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